SPION and doxorubicin-loaded polymeric nanocarriers for glioblastoma theranostics
نویسندگان
چکیده
منابع مشابه
Highly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.
Current therapy for glioblastoma multiforme is insufficient, with nearly universal recurrence. Available drug therapies are unsuccessful because they fail to penetrate through the region of the brain containing tumor cells and they fail to kill the cells most responsible for tumor development and therapy resistance, brain cancer stem cells (BCSCs). To address these challenges, we combined two m...
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BACKGROUND Advances in nanostructure materials are leading to novel strategies for drug delivery and targeting, contrast media for magnetic resonance imaging (MRI), agents for hyperthermia and nanocarriers. Superparamagnetic iron oxide nanoparticles (SPIONs) are useful for all of these applications, and in drug-release systems, SPIONs allow for the localization, direction and concentration of d...
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The aim of the present study was to develop Exemestane loaded polymeric nanoparticles for improved oral bioavailability of Exemestane. Exemestane loaded nanoparticles were prepared by solvent displacement method with Eudragit RL 100 and Eudragit L 100 as polymers and Pluronic® F-68 as surfactant. The influence of various formulation factors (drug: polymer ratio and concentration of surfactant) ...
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ژورنال
عنوان ژورنال: Drug Delivery and Translational Research
سال: 2021
ISSN: 2190-393X,2190-3948
DOI: 10.1007/s13346-020-00880-8